An optimal control problem of immuno-chemotherapy in presence of gene therapy

<abstract><p>This study addresses a cancer eradication model involving effector cells in the presence of gene therapy, immunotherapy, and chemotherapy. The main objective this is to understand optimal effect immuno-chemotherpay therapy. boundedness positiveness solutions respective feasible domains proposed are verified. Conditions for which equilibrium points system exist stable have been derived. An control problem has constructed solved minimize immuno-chemotherapy drug-induced toxicity patient. Amounts immunotherapy be injected into patient cancerous tumor found. Numerical graphical results presented. From results, it seen that can eliminated specific time interval with immuno-chemotherapeutic drug concentration.</p></abstract>